Short Term HMB-FA Supplementation Decreases Muscle Damage Markers After Soccer Matches

Eslami, Rasul; Abnama, Navab

Volume 20, Issue 24 (3-2023) RSMT 2023, 20(24): 89-102 | Back to browse issues page

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Eslami R, Abnama N. Short Term HMB-FA Supplementation Decreases Muscle Damage Markers After Soccer Matches. RSMT 2023; 20 (24) :89-102
URL: http://jsmt.khu.ac.ir/article-1-566-en.html

Short Term HMB-FA Supplementation Decreases Muscle Damage Markers After Soccer Matches

Rasul Eslami

, Navab Abnama

Allameh Tabataba’i University , eslami.rasul@gmail.com

Abstract: (2454 Views)

The aim of the present study was to investigate The effect of HMB-FA supplementation on the muscle damage markers after soccer matches. 24 male soccer players (age: 23±3 years, BMI: 22.8±2 kg/m2) were voluntarily selected as the statistical sample of this study and were divided into two Suppplement and Placebo groups (n=12). In this study, subjects participated in a weekly soccer microcycle with two matches. Subjects in the supplement-training group consumed three grams of HMB-FA daily during a weekly soccer cycle. Blood samples were taken in seven times (before supplementation, before the first match, immediately after the first match, 24 hours after the first match, before the second match, immediately after the second match, 24 hours after the second match). Plasma concentrations of creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by ELISA kits. Data analysis was performed using Friedman, Wilcoxon, Kruskal-Wallis and U Mann-Whitney tests with a significance level of p ≥ 0.05. After supplementation, a significant decrease in plasma levels of lactate dehydrogenase (before and after the first match) and creatine kinase (in the times immediately after the first match and before the second match) was observed (for all, p <0.05). Intaking HMB-FA supplement reduced the markers of muscle damage, which is essential for recovery from injuries caused by training and competition during a two race cycle. In addition, inaking HMB-FA supplement may have other effects, including reducing neuromuscular fatigue, reducing the inflammatory response, and rapid skeletal muscle regeneration, which requires further study.

Keywords: Muscle Damage, Creatine Kinase, Lactate Dihydrogenase, HMB-FA, Soccer

Full-Text [PDF 1343 kb] (888 Downloads)

Type of Study: Research | Subject: sport physiology
Received: 2022/06/2 | Accepted: 2022/11/3 | Published: 2023/03/6

References

1. 1.Andrzejewski, M., Podgórski, T., Kryściak, J., Chmura, P., Konefał, M., Chmura, J., ... & Pluta, B. (2021). Anabolic-catabolic hormonal responses in youth soccer players during a half-season. Research in Sports Medicine, 29(2), 141-154. [DOI:10.1080/15438627.2020.1734930]

2. Clemente, F. M., González-Fernández, F. T., Ceylan, H. I., Silva, R., Younesi, S., Chen, Y. S., ... & Murawska-Ciałowicz, E. (2021). Blood Biomarkers Variations across the Pre-Season and Interactions with Training Load: A Study in Professional Soccer Players. Journal of Clinical Medicine, 10(23), 5576. [DOI:10.3390/jcm10235576]

3. Correia, A. L. M., de Lima, F. D., Bottaro, M., Vieira, A., da Fonseca, A. C., & Lima, R. M. (2018). Pre-exercise β-hydroxy-β-methylbutyrate free-acid supplementation improves work capacity recovery: a randomized, double-blinded, placebo-controlled study. Applied Physiology, Nutrition, and Metabolism, (999), 1-6. (doi: 10.1139/apnm-2017-0867) [DOI:10.1139/apnm-2017-0867]

4. Dolci, F., Hart, N. H., Kilding, A. E., Chivers, P., Piggott, B., & Spiteri, T. (2020). Physical and energetic demand of soccer: a brief review. Strength & Conditioning Journal, 42(3), 70-77. [DOI:10.1519/SSC.0000000000000533]

5. Fang, B., Kim, Y., & Choi, M. (2021, December). Effect of Cycle-Based High-Intensity Interval Training and Moderate to Moderate-Intensity Continuous Training in Adolescent Soccer Players. In Healthcare (Vol. 9, No. 12, p. 1628). Multidisciplinary Digital Publishing Institute. [DOI:10.3390/healthcare9121628]

6. Holeček, M. (2017). Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions. Journal of cachexia, sarcopenia and muscle, 8(4), 529-541. doi: 10.1002/jcsm.12208 [DOI:10.1002/jcsm.12208]

7. Kellmann, M. (2010). Preventing overtraining in athletes in high‐intensity sports and stress/recovery monitoring. Scandinavian journal of medicine & science in sports, 20, 95-102. (doi: 10.1111/j.1600-0838.2010.01192.x) [DOI:10.1111/j.1600-0838.2010.01192.x]

8. Khaitin, V., Bezuglov, E., Lazarev, A., Matveev, S., Ivanova, O., Maffulli, N., & Achkasov, E. (2021). Markers of muscle damage and strength performance in professional football (soccer) players during the competitive period. Annals of Translational Medicine, 9(2). [DOI:10.21037/atm-20-2923]

9. Lowery, R. P., Joy, J. M., Rathmacher, J. A., Baier, S. M., Fuller, J. C., Shelley, M. C., ... & Wilson, J. M. (2016). Interaction of beta-hydroxy-beta-methylbutyrate free acid and adenosine triphosphate on muscle mass, strength, and power in resistance trained individuals. Journal of strength and conditioning research, 30(7), 1843-1854. (doi: 10.1519/JSC.0000000000000482) [DOI:10.1519/JSC.0000000000000482]

10. Martins, P., & Pedro, S. (2017). Motivational Regulations and Recovery in Olympic Wrestlers. International Journal of Wrestling Science, 7(1-2), 27-34. (doi: 10.1080/21615667.2017.1346345) [DOI:10.1080/21615667.2017.1346345]

11. Mousavi, S., Nourshahi, M., Qarakhanlu, R., Hedayati, M., &, Akbarnejad, A. (2018). The Acute Effect of HMB-FA Supplement and Sport Activity on Some Factors that Influence Hypertrophy and Muscle Damage in Inactive Men. Journal of Sport Biosciences, (), -. doi: 10.22059 / jsb.2018.265762.1310. (in Persian)

12. Nalbandian, M., & Takeda, M. (2016). Lactate as a signaling molecule that regulates exercise-induced adaptations. Biology, 5(4), 38. DOI: 10.3390/biology5040038. (in Persian) [DOI:10.3390/biology5040038]

13. Narimani Pi Peshteh, Azadeh; Gorkhanloo, Reza and Aghayari, Azar (2012). The effect of short-term use of HMB supplement on plasma creatine phosphokinase levels after resistance training protocol in non-athlete women. Journal of Metabolism and Exercise, Volume 2, Number 2, pp. 163-149. (in Persian)

14. Nowakowska, A., Kostrzewa-Nowak, D., Buryta, R., & Nowak, R. (2019). Blood biomarkers of recovery efficiency in soccer players. International Journal of Environmental Research and Public Health, 16(18), 3279. [DOI:10.3390/ijerph16183279]

15. Redkva, P. E., Paes, M. R., Fernandez, R., & da-Silva, S. G. (2018). Correlation between match performance and field tests in professional soccer players. Journal of human kinetics, 62, 213. [DOI:10.1515/hukin-2017-0171]

16. Silva, J. R., Ascensão, A., Marques, F., Seabra, A., Rebelo, A., & Magalhães, J. (2013). Neuromuscular function, hormonal and redox status and muscle damage of professional soccer players after a high-level competitive match. European journal of applied physiology, 113(9), 2193-2201. [DOI:10.1007/s00421-013-2633-8]

17. Silva, V. R., Belozo, F. L., Micheletti, T. O., Conrado, M., Stout, J. R., Pimentel, G. D., & Gonzalez, A. M. (2017). β-Hydroxy-β-methylbutyrate free acid supplementation may improve recovery and muscle adaptations after resistance training: A systematic review. Nutrition Research, 45, 1-9. (doi: 10.1016/j.nutres.2017.07.008) [DOI:10.1016/j.nutres.2017.07.008]

18. Soleymani Rasa, E., & Saidei, P. (2021). Dose-response of beta-hydroxy beta-methyl butyrate supplementation (HMB-FA) on muscle and liver damage indices induced by an eccentric resistance exercise session in non-athlete females. Journal of Applied Health Studies in Sport Physiology, 8(2), 34-43.

19. Tinsley, G. M., Givan, A. H., Graybeal, A. J., Villarreal, M. I., & Cross, A. G. (2018). β-Hydroxy β-methylbutyrate free acid alters cortisol responses, but not myofibrillar proteolysis, during a 24-h fast. British Journal of Nutrition, 119(5), 517-526. (doi: 10.1017/S0007114517003907) [DOI:10.1017/S0007114517003907]