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Dr Sajad Karami, Dr Hamid Rajabi, Dr Majid Kashef, Dr Mohammad Ali Gharaat,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction and purpose: The present study was conducted with the aim of investigating the effect of acute glutamine supplementation along with intermittent exercise on Hsp70 and blood lactate response of club football players. Methodology: 32 players of the Tehran Railway team were selected and randomly divided into four groups: control, supplement, supplement-sports activity, and sports-activity. Subjects participated in daily exercises before conducting the study, and only two complementary groups - sports activity and sports activity - performed the periodic protocol. Blood samples were taken at baseline, pre-test, post-test and 90 minutes after the test. The supplement and placebo were consumed in an amount of 0.5 g/kgBW and a volume of 5 ml/kgBW one hour before the periodic protocol. The interval protocol included 3 stages of 20-minute running with an intensity of 80% of the maximum heart rate and a 5-minute rest of walking between the stages. HSP72 and blood lactate levels were measured using ELISA and enzymatic methods, respectively. The data were analyzed using the analysis of variance test with repeated measures and the between-group factor at the P≤0.05 level. Findings: Glutamine supplement alone and together with exercise stimulate the response of HSP72 and the combination of supplement and exercise leads to a greater response of HSP72 and lactate changes did not play a role in this response. Discussion and conclusion: It seem that taking glutamine supplements in the long term creates more adaptations, which of course should be studied.
Mojtaba Salehpour, Faezeh Rezvani, Farzane Hatami,
Volume 0, Issue 0 (11-2019)
Abstract
Background: GDNF protein is involved in neurocognitive plasticity and sarcopenia, and the increase of GDNF due to resistance training leads to healthier aging and delays sarcopenia, and TRX resistance training improves the performance and morale of the elderly. The purpose of this research is the effect of six weeks of TRX training on the level of GDNF protein in the serum of elderly women.
Materials and methods: The purpose of the research is applied with a semi-experimental method including pre-test - post-test with control group and field and laboratory data. 28 elderly women aged 55 to 75 years old from the retirement center of Shahid Rajaee Tarbiat University of Tehran were randomly assigned to two experimental groups (15 people) with an average age of 60.86 ± 5.60, weight 75.00 ± 11.95, BMI ± 4.22 27.65 and six weeks of TRX training and the control group (13 people) with an average age of 64.38 ± 4.03, weight 72.69 ± 4.95, BMI 28.33 ± 2.18 and no training were divided. In the first and sixth weeks, both groups were tested for upper body strength, lower body strength and GDNF protein level by ELISA method.Shapiro-Wilk test was used to check the normality of data distribution, Levine's test for homogeneity of variances and one-way analysis of covariance test at a significance level of P < 0.05 was used to test hypotheses and statistical calculations were performed with spss24.
Results: In the results of covariance analysis of upper body and lower body strength, there is a significant difference between the two groups at the level of P <0.05. By removing the effect of the pre-test variable, there is a significant difference between the amount of GDNF protein in the experimental and control groups. By comparing the adjusted averages in the experimental and control groups, the amount of GDNF protein in the experimental group (443.102 ± 15.751) is significantly higher than the control group (209.756 ± 17.029) (P < 0.05).
Conclusion: Six weeks of TRX training had a significant effect on the amount of GDNF protein, upper and lower body strength of elderly women, and it can probably be effective in reducing or delaying sarcopenia.
Dr Majid Kashef, Dr Maral Ramez, Azam Ahmadi,
Volume 20, Issue 24 (3-2023)
Abstract
It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity, hospitalization, and mortality worldwide. The events associated with MI are highly complex and characterized by rapid metabolic and biochemical changes. Exercise training is an effective cardioprotective strategy that reduces adverse effects of MI and ischemia/reperfusion (I/R). Multiple signaling pathways of exercise preconditioning in mitigating MI-induced cardiac damage is one of the topics that has attracted much attention. In this article, some of the contributing factors in exercise-induced cardiac protection, including mitochondrial changes, metabolic changes, vascular adaptations, antioxidant capacity, heat shock proteins, cyclooxygenase levels, ATP-sensitive potassium channels, adenosine, protein kinase C, calcium and klotho homeostasis are discussed.
Mojtaba Salehpour, Ali Sarlak, Hadi Samadi,
Volume 21, Issue 26 (12-2023)
Abstract
Introduction: The increase of iron due to aging affects the process of ferroptosis, and the final product of lipid peroxidation, MDA, is the central regulator of ferroptosis. Therefore, the aim of the research was to determine the effect of eight weeks of endurance training on the expression of GPX4 and MDA in the soleus muscle of aged male rats.
Materials and Methods: This study is of an experimental type. 20 healthy rats were divided into two groups of 10 each: training group and control group. The training was done incrementally for eight weeks. 48 hours after the last training session, the soleus muscle of mice was surgically removed and the amount of variables was measured by gene expression and ELISA methods.
Results: There was no significant difference in the level of GPX4 gene expression in the soleus muscle of exercise group rats compared to control group rats (p=0.4079). But the amount of MDA in the training group was significantly reduced compared to the control group (p=0.0028).
Conclusion: According to the findings of the present research, it seems that the effect of endurance training in this research shows a decrease in ferroptosis. The absence of a significant difference in the level of GPX4 gene expression is a sign that endurance training with this intensity does not affect it.
Javid Shah Hosseini, Arezoo Eskandari, Mohamad Fashi,
Volume 21, Issue 26 (12-2023)
Abstract
Using standard tests to assess maximum strength is very important where resistance training planning is based individually. This study aimed to estimate 1 repetition maximum of active women based on the Rating of Perceived and to provide a special predictive equation. 30 healthy women (20-35 years; BMI: 26.32 ± 3.34 kg/m2) performed one repetition of chest press with eyes close and then chose a number to determine the intensity by Rating of Perceived Exertion scale of 6-20. In order to evaluate the validity of the designed equation, one repetition of the maximum number of subjects was calculated by Brzycki equation, and correlation was determined by Pearson's correlation method. There was a high correlation between the present study equation and the Brzycki method (r=0.89) and also after cross validations (r=0.91). No significant difference was observed between the results of the present equation and the results of Berzyski's equation. It seems that the equation of the present study” 1RM={(20-RPE" /" 40) +1 }× weight/2 " can provide a reliable estimate for 1 repetition maximum of chest press in healthy women.
Mohammad Kalantariyan, Samaneh Samadi , Ramin Beyranvand,
Volume 22, Issue 28 (12-2024)
Abstract
This research aims to investigate the changes in static and dynamic balance and proprioceptive accuracy of knee and ankle joints of young taekwondo athletes before and after applying the fatigue protocol. The current research is semi-experimental. The research subjects were 20 teenage male taekwondo players (17/86±4/4 year, 174/37±5/2 cm, 65/61±6/1 kg) from the statistical population. Static and dynamic balance variables were measured respectively by Stork's static balance test and Y dynamic balance test, as well as the proprioception of the ankle and knee joints at 10 degrees of ankle dorsiflexion and 30 degrees of knee flexion, by the photographic method. Then the functional fatigue protocol was applied. After finishing the fatigue protocol, all the variables evaluated again. The results of the paired t-test showed that after applying the fatigue protocol, there is a significant difference between the average of static (P=0.028) and dynamic balance in all three anterior (P=0.001), posterior-medial (P=0.012) and posterior-lateral (P=0.009) directions as well as proprioceptive accuracy of knee joint (P=0.003) and ankle joint (P=0.001).
It is recommended to all taekwondo coaches and athletes, to perform specialized training exercises in the field of taekwondo and according to the age of teenagers.
Fereshteh Shahidi, Hamide Ahmadi, Majid Kashef,
Volume 22, Issue 28 (12-2024)
Abstract
PRAS40 is expressed in all types of body tissues and is present in the muscle growth pathway and has multiple phosphorylation sites. Studies have shown that PRAS40 plays a role in regulating cell growth. The aim of this study was to evaluate the effect of six weeks of resistance training and whey protein supplementation on PRAS40 and biceps hypertrophy in male Wistar rats
Method:This developmental experimental study was carried out in 1402 year. 23 eight-week-old male Wistar rats (250 grams) were randomly divided into three groups: resistance training, resistance training+ supplement, and control. After two weeks of orientation, the training groups completed six weeks of resistance training, climbing the ladder five days a week. The training +supplement group received whey protein (2.05 g/kg dose) through gavage. 48 hours after the last training, a blood sample was taken and the gastrocnemius muscle was removed, frizzed, and saved to evaluate the expression of the PRAS40 gene.
Findings: Six weeks of resistance training with whey supplement caused a significant decrease in PRAS40 gene expression and an increase in body and muscle weight in the exercise and supplement + exercise groups.
Conclusion: The resistance training protocol along with her supplement can lead to muscle hypertrophy and activate the anabolic pathways in the muscle through the suppression of the PRAS40 pathway.
Sajad Karami, Hamid Rajabi, Fereshteh Shahidi, Fereshteh Golab,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction and purpose: Age-related changes in the expression of angiogenesis-stimulating and inhibitory genes are characteristics of aging and endothelial dysfunction. Aerobic exercise can stop or reduce this disorder. Considering the importance of resistance training in the rehabilitation of the elderly, the aim of this study was to investigate the compatibility of the response of the stimulating and inhibiting factors of angiogenesis after resistance exercise intervention in the elderly. Methodology: 24 elderly men with an average age of 67.75 years were selected in an accessible and purposeful manner. Blood samples were taken before and after a resistance activity session before and after 8 weeks of resistance training. Real Time PCR method was used to express HIF-1, VEGF, SDF-1 and VEGI genes in blood tissue. The difference in the values of the variables was evaluated by the method of analysis of variance with repeated measurement of mixed design at the level of P≤0.05 using SPSS software version 25. Findings: HIF-1, VEGF and SDF-1 gene expression levels of the training group increased in the stages of the primary post-test (after one session), secondary pre-test and secondary post-test (after 8 weeks of training) and VEGI had no gene expression. Discussion and conclusion: It can be cautiously said that although one session of resistance training leads to gene expression of angiogenesis factors, long-term resistance training with sufficient intensity and volume can It activates the rate of angiogenesis in a much wider range and should be considered as a supplement to aerobic exercises in old age.
