Showing 5 results for Kordi
Mr Reza Asadi, Dr Mohammad Reza Kordi, Dr Fatemeh Shabkhiz,
Volume 21, Issue 25 (9-2023)
Abstract
Neurodegenerative processes play an important role in the progression of MS. Appropriate exercise training and living in an enriched environment (EE) can improve or prevent the progression of the disease through the secretion of some neurodevelopmental factors in the hippocampus, including irisin and the neutrophic factor derived from the mouse. The aim of the present study was to investigate the effect of 4 weeks of aerobic and resistance training and EE on irisin protein and hippocampus BDNF levels in female C57BL6 mice with experimental autoimmune encephalomyelitis (EAE). 50 female mice (age 8 weeks, average weight 18 ± 2 grams) were randomly divided into five equal groups (10 mice in each group): 1- healthy control, 2- control + EAE, 3- resistance activity + EAE, 4- Aerobic activity + EAE and 5- EE + EAE. The first and second weeks of adaptation to the environment and then induction of EAE were performed. The training groups trained 5 days a week for half an hour a day for 4 weeks, and the EE group was transferred to its equipped cage. 48 hours after the last training session, the mice were anesthetized and then dissected and tissue removed. The ELISA method was used to measure the amounts of proteins, and the analysis of variance and Tukey's t-test were used to determine the differences between the research variables. All analyzes were performed at a significance level of 0.05 and with SPSS22 software. Hippocampal BDNF expression was increased in all three training groups compared to the EAE control group. This increase in the EE and resistance training group was significant compared to both the EAE control group and the swimming training group. Also, hippocampal irisin expression increased in all three training groups compared to the EAE control group, and this increase was significant in the EE and resistance training groups. Also, the expression of irisin in the EE group increased more than the two aerobic swimming and resistance training groups, and this increase was proportional to It was meaningful to the swimming aerobic training group. It seems that EE and resistance training can increase the secretion of nerve growth factors such as irisin and BDNF and thus help to improve MS disease.
Elmira Ahmadi, Shahnaz Shahrbanian, Mohamadreza Kordi, Reza Gharakhanlou, Gregory Pearcey,
Volume 22, Issue 27 (8-2024)
Abstract
Fatigue is one of the most common symptoms among individuals with multiple sclerosis (MS). The imbalance of inflammatory cytokines in the brain causes mental fatigue. It is believed that aerobic exercise may moderate the level of inflammation of cytokines and thus reduce mental fatigue. This study was conducted to investigate the effect of swimming aerobic training on pro-inflammatory factors (interleukin 6) and anti-inflammatory factors (interleukin 10) to evaluate mental fatigue in the brains of female mice after EAE induction. In this research, 21 mice (8 weeks old, 18 to 20 grams) were divided into three groups: healthy control, EAE control, and EAE swimming aerobic exercise. The animals in the training group performed moderate-intensity swimming exercises for 4 weeks, with 5 sessions per week, each session lasting 30 minutes. The western blot method was used to analyze the research variables. The results showed no significant difference in the amount of IL-6 between the EAE group and the swimming training group, but the amount of IL-10 in the swimming training group showed a significant increase compared to the EAE group. The ratio of IL-10/IL-6 values between the swimming training group and the EAE group was also not significant. It seems that moderate-intensity swimming aerobic exercises, without changing the pro-inflammatory factor, along with increasing the anti-inflammatory factor IL-10, can lead to an improvement in the balance of the inflammatory index and a reduction in fatigue in the EAE group and the swimming exercise group.
Reza Khazaei, Mansour Sahebozamani, Ehsanolla Habibi, Khosro Jalali Dehkordi, Nafise Pishgooie, Banafsheh Parvaresh,
Volume 22, Issue 28 (12-2024)
Abstract
Background and Aims:The necessity and importance of such research, especially among the young is quite tangible. The purpose of the present study was to compare the effect of 8 weeks of corrective selected exercise and combination kinesiotaping and tera band training on the kyphosis angle of adolescent boys with kyphosis. Materials and Methods: In this quasi-experimental study, spinal deformity information of 36 boy students in gym of Esfahan city, 15-18year participated in this study. Then boy student’s participated in an 8-week corrective selected exercise and Combination of Kinesiotaping and Teraband، the end their deformity were evaluated again.For data analysis descriptive statistics ، T tests and SPSS Software was used.The angleof kyphosis in pre-test (48/8± 0/9) after using corrective selected exercise have had a significant reduction (46/9±0/8). Angle of kyphosis in pre-test (49. 1 ± 0.7) after using Combination of Kinesiotaping and Teraband have had a significant reduction (46/97±0/8). Conclusion:corrective exercises alone or in combination with new methods of training, the subjects had a positive impact on improving the kyphosis. But according to the results of this study, no significant difference was found between the corrective exercises with the combined method.
Samira Emadi, Shahnaz Shahrbanian, Mohammadreza Kordi, Mahdieh Molanouri Shamsi,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction:Disruption of the homeostasis of immune regulatory mediators Aryl hydrocarbon receptor (AhR) and Ornithine decarboxylase-1(ODC-1) is involved in the pathogenesis of multiple sclerosis (MS). Physical activities play a role in controlling and improving the symptoms of MS. This study aimed to investigate the effect of 4 weeks of physical activity in enriched movement environment on the gene expression of AhR and ODC-1 in the cerebellum tissue of an MS mice model.
Method: This experimental study was conducted on 30 female C57BL/6 mice (age: 8 weeks and average weight: 18 ± 2). Mice were divided into 3 groups of 10 including 1) healthy control, 2) Induction of experimental autoimmune encephalomyelitis (EAE) and 3) EAE + physical activity in enriched movement environment for 4 weeks. Clinical score were recorded daily from induction until 28 days. The gene expression of AhR and ODC-1 in the cerebellum was measured by RT-PCR method. Statistical analysis of the data was performed using one-way analysis of variance.
Results: Activity in the enriched movement environment significantly decreased the gene expression of AhR compared to the EAE group (P=0/02) and also decreased the gene expression of ODC-1, but it was not statistically significant (P=0/28). Also, the clinical score improved significantly after activity in the enriched movement environment (P= 0/001).
Conclusion: In general, it seems that lifestyle change and activity in enriched movement environment lead to the down regulation of the gene expression of AhR and ODC-1 in the cerebellum and improved the clinical score of animals with MS.
Hamid Abbasi Bafghi, Mohammad Hasan Kordi Ashkezari, Abdolmajid Heratizadeh, Saeed Abedinzadeh,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction and Objective: Ankle injuries are among the most common sports-related injuries, often caused by factors such as "direct contact with a player or the ground, tackles that push the ankle inward or outward, and during jumping and landing." Among these injuries, lateral ankle sprains are one of the most prevalent types, frequently associated with ankle instability. The aim of this study was to compare the effects of balance training and hopping exercises on the proprioception of athletes with functional ankle instability.
Methods: A total of 30 basketball, volleyball, and handball athletes with functional ankle instability, with a mean age of 24.58 ± 3.626 years and a body mass index (BMI) of 25.681 ± 2.126, were randomly assigned to two groups in a clinical trial. The first group (n=15) performed hopping exercises, while the second group (n=15) performed balance training. Proprioception of their ankle joints was assessed at baseline and after six weeks of training. Data analysis was conducted using paired t-tests and ANCOVA via SPSS version 20.
Results: Both balance training and hopping exercises significantly reduced the absolute error in reconstructing dorsiflexion and plantarflexion angles of the ankle (p<0.05). Additionally, the reduction in absolute error for these angles was significantly greater in the hopping group compared to the balance training group (p<0.05).
Conclusion: The findings indicate that both balance training and hopping exercises improve ankle joint proprioception in athletes with functional ankle instability. However, hopping exercises demonstrated greater effectiveness compared to balance training.
