Mrs Samaneh Agha-Mohammadi, Dr Mahdieh Molanouri Shamsi, Dr Hosain Adibi,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction: Diabetes is a progressive metabolic disease that activates the immune system and increases certain inflammatory cytokines, including IL-17. One of the complications associated with diabetes affects the brain and nervous system, leading to cognitive dysfunction. Physical activities are effective in improving the condition of diabetic patients. This study aimed to investigate the effect of a multi-task combined home exercise program on serum levels of the cytokine interleukin-17 and cognitive function in women with type 2 diabetes.
Methods: Seventy patients with type 2 diabetes were randomly divided into two groups: exercise and control. The exercise group participated in a multi-task combined home-based exercise program for three months. Blood markers, cognitive function, and body composition were measured before and after the intervention. The results were analyzed using SPSS software, with a significance level of P<0.05.
Results: The present study showed that the combined exercise program led to a reduction in the inflammatory cytokine IL-17 (P<0.05). Although cognitive function showed relative improvement, the results were not statistically significant (P>0.05). Concurrently, fasting blood glucose decreased in the exercise group (P<0.05), and some body composition indices, particularly body fat percentage, improved (P<0.05).
Conclusion: Home-based combined exercise programs were associated with a reduction in the inflammatory cytokine IL-17 and a relative improvement in cognitive function in diabetic patients. The potential improvement in immune responses following these exercises may contribute to the reduction of serum IL-17 levels.
Samira Emadi, Shahnaz Shahrbanian, Mohammadreza Kordi, Mahdieh Molanouri Shamsi,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction:Disruption of the homeostasis of immune regulatory mediators Aryl hydrocarbon receptor (AhR) and Ornithine decarboxylase-1(ODC-1) is involved in the pathogenesis of multiple sclerosis (MS). Physical activities play a role in controlling and improving the symptoms of MS. This study aimed to investigate the effect of 4 weeks of physical activity in enriched movement environment on the gene expression of AhR and ODC-1 in the cerebellum tissue of an MS mice model.
Method: This experimental study was conducted on 30 female C57BL/6 mice (age: 8 weeks and average weight: 18 ± 2). Mice were divided into 3 groups of 10 including 1) healthy control, 2) Induction of experimental autoimmune encephalomyelitis (EAE) and 3) EAE + physical activity in enriched movement environment for 4 weeks. Clinical score were recorded daily from induction until 28 days. The gene expression of AhR and ODC-1 in the cerebellum was measured by RT-PCR method. Statistical analysis of the data was performed using one-way analysis of variance.
Results: Activity in the enriched movement environment significantly decreased the gene expression of AhR compared to the EAE group (P=0/02) and also decreased the gene expression of ODC-1, but it was not statistically significant (P=0/28). Also, the clinical score improved significantly after activity in the enriched movement environment (P= 0/001).
Conclusion: In general, it seems that lifestyle change and activity in enriched movement environment lead to the down regulation of the gene expression of AhR and ODC-1 in the cerebellum and improved the clinical score of animals with MS.
