It is estimated that by 2035, more than 130 million adults will suffer from various types of cardiovascular diseases. Therefore, it is very important to know the pathogens of cardiac diseases and investigate new treatments. Also, despite continuous progress in diagnosis, patient education, and risk factor management, myocardial infarction (MI) remains one of the most common causes of morbidity, hospitalization, and mortality worldwide. The events associated with MI are highly complex and characterized by rapid metabolic and biochemical changes. Exercise training is an effective cardioprotective strategy that reduces adverse effects of MI and ischemia/reperfusion (I/R). Multiple signaling pathways of exercise preconditioning in mitigating MI-induced cardiac damage is one of the topics that has attracted much attention. In this article, some of the contributing factors in exercise-induced cardiac protection, including mitochondrial changes, metabolic changes, vascular adaptations, antioxidant capacity, heat shock proteins, cyclooxygenase levels, ATP-sensitive potassium channels, adenosine, protein kinase C, calcium and klotho homeostasis are discussed.
