Ssaeedeh Shiri Lord, Roghayeh Fakhrpour, Karim Azali Alamdari,
Volume 0, Issue 0 (11-2019)
Abstract
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.
Keywords: continuous aerobic exercises, Alzheimer's, sarcopenia, muscle myofibril
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.
R Shiri, H Nikbakht, M Gholami, Kh Ebrahim,
Volume 18, Issue 19 (7-2020)
Abstract
Time under Tension of muscle is one of the variables of strength training that contributes to its adaptation. The present study was conducted the effects of six weeks of resistance training with the varying Time under Tension of muscle on VEGF and endosotene serum levels in healthy young women. This study was conducted on 20 female students (22.65±2.03years) Subjects were randomly and equally assigned to two groups with a Time under Tension of 1s- 1s(Normal Speed Contraction) and 3s- 3s (slow Speed Contraction). The exercise load was the same in both groups and resistance training was done in a circular manner for six weeks, three days a week in eight stations. Blood samples were taken from the subjects to study research variables before the training period and 48h after the last session of the training. Data were analyzed by covariance analysis at a significant level of P≤0.05. There was no significant difference between the serum levels of VEGF and endostein in both groups (P≥0.05). In the strength test, the SSC group experienced increase power further. However, there was no difference between the two groups in indicators related to angiogenesis for six weeks and most probably, for this indicator needed more training time, but practice with more Time under Tension (3s- 3s) can lead to increase power further.
Dr Shirin Yazdani, Prof Nader Farahpour,
Volume 19, Issue 21 (9-2021)
Abstract
Background and Objective: although it is documented that the spine and hip alignments alter in scoliosis subjects, but the effect of these changes on the lower extremities’ biomechanics have not been well understood yet. So, the aim of this study was to compare hip, knee and ankle joint’s power generation and absorption during gait in patients with adolescent idiopathic scoliosis (AIS) and healthy controls. Methods: Using motion analysis system with 4 Vicon-460 cameras and two Kistler force plates, the kinematics and kinetics of gait was assessed in twenty girls with AIS and 20 matched healthy controls, then the power of the right and left hip, knee and ankle joints in sagittal plane was calculated. Data was analyzed using ANOVA statistical method with significance level of α<0.05. Results: Results showed that in scoliosis group, the peak power absorption of the right knee was significantly 12.5% smaller than that in control group (p=0.01). But, peak power generation and absorption of the hip and ankle joints in both right and left limbs were not statistically differed between the two groups (p>0.05). Conclusion: scoliosis is associated with the smaller power absorption of the knee joint at convex side. This might be linked with unilateral alterations of the joints' moment, joint forces, and the related muscle activity which might impose asymmetrical force to the hip and cause curve progression.
Fadideh Alabaf Yousefi, Roghayeh Pouzesh Jadidi, Jabbar Bashiri, , Javad Vakili,
Volume 19, Issue 22 (12-2021)
Abstract
Background and Objective: the aim was to investigate the effects of 12 weeks of High Intensity Interval Training (HIIT) and curcumin supplementation on expression levels of FSTL1 and Smad7 and also Type I, III and IV collagens in rat model with myocardial infraction (MI). Methodology: 48 male rats were randomized into five groups of Reference, HIIT, Curcumin, Concomitant (HIIT+ Curcumin) and Control, following isoproterenol induced myocardial infarction. After Reference group execution in order to conform the MI, curcumin was administrated through oral gavage 15 mg/kg.day. HIIT sessions were conducted for five days per week, each session for 60 minutes, consisted of 10 bouts (each for 4 min) of running repetitions at 85-90% of v VO2 peak separated by 2 min active rest intervals between running periods. Left ventricular FSTL1, Smad7 and also type I, III and IV collagens expression level was detected by western blotting. Results: In all three intervention groups of HIIT, Curcumin and Concomitant, the cardiac weight was significantly higher (p=0.001, p=0.018 and p=0.001 respectively), while type IV collagen expression level was significantly lower (p=0.001 in any circumstances) than Control group. However, only in the Concomitant group, a significantly lower type III collagen (p=0.033) expression level as well as higher FSTL1 (P=0.001) and Smad7 (P=0.008) expressions were recorded, compared to the Control group. Conclusion: A diminished cardiac type IV collagen expression level in accompany with a zero mortality rate in all three interventions could likely imply on the safety of HIIT as well as curcumin supplementation to suppress post infraction myocardial fibrosis. However, only concomitant intervention could decrease infracted left ventricular type III collagen expression level, with an elevated FSTL1 and Smad7 expressions, which outlines their synergistic prescription to achieve better results. However, more researches remains to be done because of the lack of evidence and study limitations.
