Aliakbar Fazel, Laleh Bagheri, Nader Rahnema, Samira Emadi,
Volume 0, Issue 0 (11-2019)
Abstract
Background: In rehabilitation medicine using targeted and personalized approaches are proposed, so that training protocols adjustments, based on gender, age, level of disability and the rate of progress can have more favorable results. The purpose of this study was to investigate the effect of personalized comprehensive rehabilitation training on some induces of physical function in women with MS presenting different levels of disability.
Material & Methods: In this quasi-experimental study, 92 patients admitted to the MS Society of Shahrekord city were selected and on the basis of disability were categorized into 3 groups of mild, moderate and severe. Then each group was randomly divided into experimental and control group. The personalized comprehensive rehabilitation training program was done 12 weeks, 3 times per weeks. Muscles strength, endurance and speed of walking, were assessed. Independent and Covariance test were used for data analysis.
Results: The results showed that 12 weeks training cause improving in muscles strength, speed of walking in women with MS presenting different levels of disability (p<0.05). Endurance of walking improve significantly in mild group (p<0.05), but in moderate and severe group were not significantly (P˃0.05).
Conclusion: The implementation of the comprehensive rehabilitation exercises affected the recovery of patients with MS and made a significant difference in physical functions of patients.
Samira Emadi, Shahnaz Shahrbanian, Mohammadreza Kordi, Mahdieh Molanouri Shamsi,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction:Disruption of the homeostasis of immune regulatory mediators Aryl hydrocarbon receptor (AhR) and Ornithine decarboxylase-1(ODC-1) is involved in the pathogenesis of multiple sclerosis (MS). Physical activities play a role in controlling and improving the symptoms of MS. This study aimed to investigate the effect of 4 weeks of physical activity in enriched movement environment on the gene expression of AhR and ODC-1 in the cerebellum tissue of an MS mice model.
Method: This experimental study was conducted on 30 female C57BL/6 mice (age: 8 weeks and average weight: 18 ± 2). Mice were divided into 3 groups of 10 including 1) healthy control, 2) Induction of experimental autoimmune encephalomyelitis (EAE) and 3) EAE + physical activity in enriched movement environment for 4 weeks. Clinical score were recorded daily from induction until 28 days. The gene expression of AhR and ODC-1 in the cerebellum was measured by RT-PCR method. Statistical analysis of the data was performed using one-way analysis of variance.
Results: Activity in the enriched movement environment significantly decreased the gene expression of AhR compared to the EAE group (P=0/02) and also decreased the gene expression of ODC-1, but it was not statistically significant (P=0/28). Also, the clinical score improved significantly after activity in the enriched movement environment (P= 0/001).
Conclusion: In general, it seems that lifestyle change and activity in enriched movement environment lead to the down regulation of the gene expression of AhR and ODC-1 in the cerebellum and improved the clinical score of animals with MS.
