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The Impact Of High-Intensity Interval Training On Cardiometabolic Factors In Adults With Overweight And Obesity: A Systematic Review And Meta-Analysis
Fatemeh Kazeminasab, Motahareh Mohebinejad, Karim Azali Alamdari,
Volume 23, Issue 29 (7-2025)
Abstract
Aim: Excessive fat deposition is associated with cardiovascular diseases, diabetes as well as hypertension. The aim of this study was to determine the net effect size of high intensity interval training (HIIT) on some factors associated with insulin sensitivity in adults with overweight and obesity.
Methods:  A search for English articles was conducted in Web of Science, Scopus, and PubMed databases without limiting the year of publication until February 2023. To calculate the effect size, WMD and 95% confidence interval were calculated using random effect model. Fixed effect model meta regression was used to determine treatment effects associations with other variables.
Results: In total, 13 studies with 446 adults with overweight and obesity (149 females, and 317 males) with 24.7-57 years old were included in the present meta-analysis. The results showed that HIIT caused a significant decrease in fasting glucose [WMD=-8.65 mg/dL, P=0.002], fasting insulin [WMD=-1.88 U/L P=0.005], and diastolic blood pressure (DBP) [WMD=-3.33 mmHg. Weak correlations were observed in between HIIT’s net effect on DBP and insulin (r=-0.32, p=0.019) as well as with subjects’ age (r=-0.29, p=0.037) respectively in meta-regression assessments.
Conclusion: The rate of DBP reduction is sharper and these changes are also correlated with age. Therefore, HIIT is suggested as a Non-pharmacological Approach to prevent against future cardiometabolic risk factors in this population.

Sports Talent Based On Genetic Profile: Narrative Review
Kia Ranjbar,
Volume 23, Issue 29 (7-2025)
Abstract 
Introduction: The purpose of the present study is to introduce and examine several genes that are related to people's sports performance and can be effective in their selection and selection in their favorite sports field. Various factors of physical fitness and training ability have been investigated along with the risk of sports injury and mental fitness of athletes.
Findings: The sports performance of people and the monitoring of sports exercises have been influenced by the vast genetic map and environmental interventions. In the present study, the performance of the aerobic system with the ACE gene and its different alleles, the strength and power performance of people with the ACTN3 gene, and the risk of injury of people with different genes such as COL1A1, COL5A1, Tenascin (TNC), apolipoprotein E and blood groups were investigated. It is a prediction; also, the trainability and mental preparation of people in the talent search process can be predicted and possibly measured by genetic knowledge. On the other hand, using the knowledge of genetics and genetic profiles of athletes can be useful for detecting genetic and cellular doping and help organizations that work in the prevention of doping, such as WADA.
Conclusion: The combination of genetic knowledge and environmental interventions play an effective role not only in discussing an athlete's talent, but also in monitoring and improving their performance. While genetics can play a significant role, the prediction of sports success based on genetic knowledge has been limited to a specific set of genes. However, developing this knowledge and identifying more genes that can aid in talent identification and exercise monitoring requires further research.

Examining Adaptation In The Response Of Stimulatory And Inhibitory Genes Of Angiogenesis After Resistance Exercise Intervention In Older Adults’ Men
Sajad Karami, Hamid Rajabi, Fereshteh Shahidi, Fereshteh Golab,
Volume 23, Issue 29 (7-2025)
Abstract
Introduction and purpose: Age-related changes in the expression of angiogenesis-stimulating and inhibitory genes are characteristics of aging and endothelial dysfunction. Aerobic exercise can stop or reduce this disorder. Considering the importance of resistance training in the rehabilitation of the elderly, the aim of this study was to investigate the compatibility of the response of the stimulating and inhibiting factors of angiogenesis after resistance exercise intervention in the elderly. Methodology: 24 elderly men with an average age of 67.75 years were selected in an accessible and purposeful manner. Blood samples were taken before and after a resistance activity session before and after 8 weeks of resistance training. Real Time PCR method was used to express HIF-1, VEGF, SDF-1 and VEGI genes in blood tissue. The difference in the values of the variables was evaluated by the method of analysis of variance with repeated measurement of mixed design at the level of P≤0.05 using SPSS software version 25. Findings: HIF-1, VEGF and SDF-1 gene expression levels of the training group increased in the stages of the primary post-test (after one session), secondary pre-test and secondary post-test (after 8 weeks of training) and VEGI had no gene expression. Discussion and conclusion: It can be cautiously said that although one session of resistance training leads to gene expression of angiogenesis factors, long-term resistance training with sufficient intensity and volume can It activates the rate of angiogenesis in a much wider range and should be considered as a supplement to aerobic exercises in old age.

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