Showing 3 results for Angiogenesis
Dr Rasoul Eslami,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction: Blood flow restriction (BFR) has been shown to induce local hypoxia. Therefore, the purpose of this study was to investigate the effect of BFR-induced hypoxia on the angiogenic response to high-intensity interval exercise (HIIE). Methods: Thirty active young men (age =25.6±3.4) were randomly assigned to three groups (n=10 each): control, high-intensity interval exercise (HIIE), and high-intensity interval exercise with blood flow restriction (HIIE+BFR). The HIIE protocol consisted of 5 sets of 5×30-second high-intensity running intervals with 30-second rest periods. BFR was applied at 60% of each individual's optimal occlusion pressure in the lower limbs. Serum levels of VEGF, HIF-1α, MMP-9, and MMP-2 were measured as angiogenic markers. Statistical analysis was performed using ANCOVA with LSD post-hoc test, with the significance level set at α=0.05. Results: The data revealed that compared to both the control and HIIE groups, the HIIE+BFR group showed significantly greater increases in serum VEGF and HIF-1α levels (P=0.002 and P=0.019, respectively). However, no significant differences were observed among groups for MMP-9 and MMP-2 levels (P=0.318 and P=0.101, respectively). Conclusion: This study demonstrated that combining HIIE with BFR can enhance the angiogenic response through increased VEGF and HIF-1α levels, but does not significantly affect MMP-2 and MMP-9. These findings support the notion that BFR-induced local hypoxia may serve as a complementary stimulus for improving vascular adaptations.
F Shahidi, A Ahmadi,
Volume 17, Issue 18 (12-2019)
Abstract
The aim of this study was comparing professional futsal practice sessions with and without blood flow restriction on angiogenesis and angiostatin stimulation in active young men. Among physical education students, 12 volunteer selected and randomly divided into two groups of exercise with and without blood restriction. All of the subjects did the 3 vs. 3 professional futsal practice in 6 repetition of two minutes. One minute determined as resting time between the repetitions. In exercise group with blood restriction, a cuff on the thighs with pressure of 140 Mm Hg were applied. The blood samples were collected before and after the exercise sessions to determine the ratio and values of VEGF and endostatin concentration. Elisa method was used to measure the variables. To determine within and between group differences, Paired T test and Independent T test were used respectively at significance level of 0.05. The results showed no significant differences for the measured variables between the groups. However, VEGF significantly decreased in the two groups after exercise session (P=0.002). The ratio of VEGF to endostatin significantly increased in exercise with blood flow restriction group (P=0.002), but not in the Exercise group (P=0.006). Interestingly, the endostatin concentration increased significantly after the trial (BFR: P=0.003, NONBFR: P=0.005). Blood lactate was significantly higher in exercise group with blood restriction(P=0.003). In conclusion, a professional futsal practice session can decrease blood level of VEGF and increase its endostatin.
R Shiri, H Nikbakht, M Gholami, Kh Ebrahim,
Volume 18, Issue 19 (7-2020)
Abstract
Time under Tension of muscle is one of the variables of strength training that contributes to its adaptation. The present study was conducted the effects of six weeks of resistance training with the varying Time under Tension of muscle on VEGF and endosotene serum levels in healthy young women. This study was conducted on 20 female students (22.65±2.03years) Subjects were randomly and equally assigned to two groups with a Time under Tension of 1s- 1s(Normal Speed Contraction) and 3s- 3s (slow Speed Contraction). The exercise load was the same in both groups and resistance training was done in a circular manner for six weeks, three days a week in eight stations. Blood samples were taken from the subjects to study research variables before the training period and 48h after the last session of the training. Data were analyzed by covariance analysis at a significant level of P≤0.05. There was no significant difference between the serum levels of VEGF and endostein in both groups (P≥0.05). In the strength test, the SSC group experienced increase power further. However, there was no difference between the two groups in indicators related to angiogenesis for six weeks and most probably, for this indicator needed more training time, but practice with more Time under Tension (3s- 3s) can lead to increase power further.
