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Showing 3 results for Blood Flow Restriction
Effect of Blood Flow Restriction-induced Hypoxia on Angiogenic Response to High Intensity Interval Exercise
Dr Rasoul Eslami,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction: Blood flow restriction (BFR) has been shown to induce local hypoxia. Therefore, the purpose of this study was to investigate the effect of BFR-induced hypoxia on the angiogenic response to high-intensity interval exercise (HIIE). Methods: Thirty active young men (age =25.6±3.4) were randomly assigned to three groups (n=10 each): control, high-intensity interval exercise (HIIE), and high-intensity interval exercise with blood flow restriction (HIIE+BFR). The HIIE protocol consisted of 5 sets of 5×30-second high-intensity running intervals with 30-second rest periods. BFR was applied at 60% of each individual's optimal occlusion pressure in the lower limbs. Serum levels of VEGF, HIF-1α, MMP-9, and MMP-2 were measured as angiogenic markers. Statistical analysis was performed using ANCOVA with LSD post-hoc test, with the significance level set at α=0.05. Results: The data revealed that compared to both the control and HIIE groups, the HIIE+BFR group showed significantly greater increases in serum VEGF and HIF-1α levels (P=0.002 and P=0.019, respectively). However, no significant differences were observed among groups for MMP-9 and MMP-2 levels (P=0.318 and P=0.101, respectively). Conclusion: This study demonstrated that combining HIIE with BFR can enhance the angiogenic response through increased VEGF and HIF-1α levels, but does not significantly affect MMP-2 and MMP-9. These findings support the notion that BFR-induced local hypoxia may serve as a complementary stimulus for improving vascular adaptations.
Response of ostosis metabolic markers to aerobic exercise with blood flow restriction and vitamin D supplement among middle aged females
M Naghibi,
Volume 17, Issue 17 (4-2019)
Abstract
Osteoporosis is characterized by low bone mineral density resulting into an increased risk of fracture (9). The aim of the study is determine the effect of aerobic exercise with blood flow restriction (BFR) and vitamin D supplementation on ostosis metabolic markers (OMM) among middle aged females. In this study 30 females with age of 42.76±7.44, height of 157.90±5.74, weight of 70.55±9.68 and BMI of 28.33±3.87, divided in three groups of 10 subjects, randomly. Two empirical Groups with and without BFR, both with vitamin D supplementation, one hour before training, performed aerobic exercise during eight weeks, three days a week, one hour a day, with 50 - 70% intensity of maximal heart rate. Density of OMM, calcium, phosphorous and alkaline phosphate examined in lab, 48 hours before and after training period in saving status before breakfast. Aerobic power of empirical groups determined with 12 minutes run/ walking cooper test. For data analysis used descriptive statistics, ANOVA and analysis variance with repeated measures. Results showed that eight weeks exercise with BFR and vitamin D supplementation, the density of calcium and phosphorous increased significantly. The density of Alkaline - phosphate did not show variation significantly. In the other hand, only the rate of calcium showed variation significantly, which increased in without BFR more than others. In conclusion, aerobic exercise with and without BFR and vitamin D supplementation can increase the density of OMM, calcium, phosphorous and alkaline- phosphate. But only the density of calcium showed increasing significantly.

Comparing professional futsal practice sessions with and without blood restriction on angiogenesis and angiostatin stimulation in active young men
F Shahidi, A Ahmadi,
Volume 17, Issue 18 (12-2019)
Abstract
The aim of this study was comparing professional futsal practice sessions with and without blood flow restriction on angiogenesis and angiostatin stimulation in active young men. Among physical education students, 12 volunteer selected and randomly divided into two groups of exercise with and without blood restriction. All of the subjects did the 3 vs. 3 professional futsal practice in 6 repetition of two minutes. One minute determined as resting time between the repetitions. In exercise group with blood restriction, a cuff on the thighs with pressure of 140 Mm Hg were applied. The blood samples were collected before and after the exercise sessions to determine the ratio and values of VEGF and endostatin concentration. Elisa method was used to measure the variables. To determine within and between group differences, Paired T test and Independent T test were used respectively at significance level of 0.05. The results showed no significant differences for the measured variables between the groups. However, VEGF significantly decreased in the two groups after exercise session (P=0.002). The ratio of VEGF to endostatin significantly increased in exercise with blood flow restriction group (P=0.002), but not in the Exercise group (P=0.006). Interestingly, the endostatin concentration increased significantly after the trial (BFR: P=0.003, NONBFR: P=0.005). Blood lactate was significantly higher in exercise group with blood restriction(P=0.003). In conclusion, a professional futsal practice session can decrease blood level of VEGF and increase its endostatin. 
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