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Volume 12, Issue 7 (4-2014)
Abstract
Introduction: This research aimed to analyze the effect of 12 weeks aerobic exercise training on some
characteristics of immune system and general health of women with breast cancer. Methods: 40 female
with breast cancer, undertaking chemotherapy, were classified in exercise group with mean age of 36/9±13/2
years, weight of 67/2±9/95 kilograms and body mass index of 21/9±2/9 kg/m2 and control group with mean
age of 38/6±10/1 years, weight of 65/1±8/28 kilograms and body mass index of 21/4±2/1kg/m2. Exercise
group Perfored in 12 contionous weeks walking with moderate intensity (based on Modified-Borg scale and
40-60% Maximum Heart rate)/3 times a week/30-45 minutes in each session. General Health Questionnaire
(GHQ) was used for evaluating general health level. Before and after 4, 8 and 12 weeks CBC DIFF test was
conducted for aim of assessing some characteristics of immune system. CANCOVA was used to determine
the pure effect of exercise intervention. The data were analyzed with significant level of p≤0/05 and by SPSS
16. Results: General health and hope of life was decreased significantly after intervention in control group
(p≤0.05). Number of leukocytes of exercise group was higher after the exercise intervention, but this
difference was not significant, but number of leukocytes of control group was decreased significantly
(p≥0.05). Conclusion: Regular aerobic exercise with moderate intensity is an effective way in maintenance
the number of leukocytes, improving immune system and enhancing levels of general health.
Mr Vahid Sotoodeh, Dr Reza Gharakhanloo, Mrs Solmaz Khaligh Fard, Mrs Samaneh Khaligh Fard, Dr Alimohammad Alizadeh,
Volume 15, Issue 14 (10-2017)
Abstract
Introduction: The decorin is a myokine that modulates the growth and the development of the cancer cells through the interaction with TGF-β. The present study is aimed to evaluate the protective effects of 8 weeks interval aerobic exercise on the expression of decorin and TGF-β, and tumor volume in a typical animal of breast tumor. Materials and Methods: In a exprimental research, forty adult female Balb/c mices were randomly divided into four groups: control, tumor, exercise, and exercise with the tumor. The main exercise was performed four weeks before and after tumor with 50-70 percent of the maximum power of mices. The mices were cancerous by subcutaneous surgery with tumor of adenocarcinoma of mice breast in the tumor group and the exercise group with the tumor. Tumor growth was measured weekly. At the end of the study, tumor and soleus muscle were extracted by surgery. Real-Time PCR method was used to evaluate the expression of decorin and TGF-β and data were analyzed by t-test, one-way ANOVA and post-hoc methods with considering the significant level of p<0.05. Results: The tumor growth rate in tumor group was significantly higher than the exercise group with the tumor. A significant difference confirmed between four groups In the level of decorin expression in soleus muscle (F=12.30 , P=0.0023). The Post hoc test showed that 8 weeks of interval aerobic training significantly increased the expression of decorum gene in soleus muscle in two pairs of exercise group compared with control group and exercise group with tumor compared to tumor group (P=0.02). The expression of TGF-β in tumor tissue showed a significant reduction in exercise group with tumor compared with tumor group. Conclusion: Our results showed that interval aerobic training probably contributes to decreasing the growth of breast cancer cells by increasing the expression of decorin and decreasing the expression of TGF-β.
Sh Mirdar Harijani, N Musavi,
Volume 18, Issue 19 (7-2020)
Abstract
The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exercise training consisted of submaximal swimming training for 12 weeks. The percentage of reaction of Ras and Raf-1 in lung epithelial cells were measured by HIC. It was observed no significant change in the Ras and Raf-1 immunoreactivity of lung epithelial cells in training group compared to control. A significant incretion of the Ras and Raf-1 immunoreactivity was found in NNK group compared to control group (p=0.001). Furthermore, a significant reduction of the Ras and Raf-1 immunoreactivity was observed in exercise + NNK group when compared to NNK group (p=0.001). Generally it could be confirmed that regular submaximal aerobic training plays an important role in inhibition of the effects of lung carcinoma induced by NNK via reduction of Ras and Raf-1 activity.
Elham Shahabpoor, Mohammad Amin Delavari,
Volume 21, Issue 26 (12-2023)
Abstract
Cachexia syndrome and the risk of cardiovascular diseases are highly prevalent in cancer patients.The purpose of the present study was to investigate the effect of endurance training as a therapeutic method on muscle cachexia and cardiovascular consequences caused by breast cancer. After 2 weeks of breast cancer induction, 20 BALB/c mice (age: 6-8 weeks and weight: 17- 18 g) mice performed the maximum aerobic capacity test and were randomly allocated into tumor-control and tumor-exercise groups. The tumor-exercise group performed the endurance Training protocol for 6 weeks, 5 days a week with gradual increase in intensity from 12 to 20 (m.min-1) and duration from 25 to 55 minutes And 24 hours after the last training session, the maximum aerobic capacity test was performed. 48 hours after the last training session, the mice were sacrificed. Heart weight, weight of gastrocnemius and soleus muscle, heart mass index, ratio of weight of soleus muscle to body weight and ratio of weight of gastrocnemius muscle to body weight were measured in tumor-control and tumor-exercise groups. Data were analyzed by independent t-test at the significance level of P≥0.05. The results of the present study showed a significant increase in heart weight (P=0.005), spleen weight (P=0.029), weight of the gastrocnemius muscle (P=0.009) and soleus muscle (P=0.022) in the tumor-exercise group compared to the tumor-control group. Also, significant increase in the heart mass index (P=0.016) and the ratio of the weight of the gastrocnemius muscle to the body weight (P=0.005) and the ratio of the soleus muscle to the body weight (P=0.021) were observed in the tumor-exercise group compared to the tumor-control group. In conclusion,Endurance training seems to be a potential treatment method and strategy to improve the health of the skeletal muscle and cardiovascular system and reduce the process of muscle cachexia caused by breast cancer.
