Abbas Laal Sazegar, Shahram Gholamrezaei Darsara, Mohammadreza Fadai Chafi,
Volume 0, Issue 0 (11-2019)
Abstract
Exercise training and rice bran have anti-inflammatory effects. However, the effect of combining the two interventions on inflammatory factors is unclear. Therefore, the present study aimed to investigate the effect of aerobic training and rice bran consumption on the levels of selected inflammatory factors in overweight men. Sixty overweight men were randomly divided into four groups (n=15): control, rice bran, progressive aerobic training, and training + rice bran. Progressive aerobic training was performed at an intensity of 60-75% of maximum heart rate for, 20-35 min, 8 weeks, with 3 sessions per week. Rice bran was consumed in an amount of 10 grams twice a day (before breakfast and before sleeping). Before and after the completion of the interventions, blood samples were taken and serum levels of CRP, IL-6, and TNF-α were measured by ELISA. Analysis of covariance with Bonferroni post hoc test was used to interpret the data. There were significant decreases in the levels of CRP, IL-6, and TNF-α with training and training + rice bran compared to the control and rice bran groups (p<0.05). The CRP and TNF-α reduction was also significant after rice bran consumption compared to the control group (p<0.001). Moreover, decrease in the levels of IL-6 (p=0.002) and TNF-α (p<0.001) in the training +rice bran group compared to the training group was also significant. The findings confirmed that aerobic training and rice bran consumption are effective in reducing inflammation, and there was a synergistic effect of rice bran supplementation and aerobic training.
Kia Salimi, Ali Asghar Ravasi, Siroos Choobineh, Kamran Rakhshan ,
Volume 0, Issue 0 (11-2019)
Abstract
Abstract
Introduction and purpose: Structural remodeling of the heart following myocardial infarction often leads to heart failure, a condition characterized by impaired cardiac function and increased hemodynamic load. Inflammation, oxidative stress, and ventricular remodeling play key roles in the pathogenesis of heart failure. This study aimed to investigate the effects of combined administration of propionate and low-volume HIIT on inflammatory status and cardiac function in mice with heart failure.
Methodology: Forty male Wistar rats (8 weeks old, 200–250 g) were induced with HF by isoproterenol injection (130 mg/kg) and randomly assigned to five groups: (1) Control, (2) heart failure, (3) heart failure + Propionate, (4) heart failure + HIIT, and (5) heart failure + HIIT + Propionate. HIIT consisted of 10 one-minute bouts with a 1:1 work-to-rest ratio, performed over 6 weeks. Propionate was administered orally at a dose of 1000 mg/kg prior to each training session. Cardiac function was assessed by echocardiography, and cytokine levels were measured using ELISA. Data were analyzed using one-way ANOVA (p<0.05).
Findings: Both HIIT and propionate individually improved cardiac function and inflammatory markers. The combined intervention significantly increased ejection fraction (p = 0.038) and fractional shortening (p=0.023), reduced TNF-α (p=0.0061), and increased IL-10 levels (p=0.0007), yielding superior outcomes compared with individual treatments.
Discussion and conclusion: This study demonstrates that the combination of propionate supplementation with low-volume HIIT effectively improves inflammation and cardiac function in rats with heart failure.
Elmira Ahmadi, Shahnaz Shahrbanian, Mohamadreza Kordi, Reza Gharakhanlou, Gregory Pearcey,
Volume 22, Issue 27 (8-2024)
Abstract
Fatigue is one of the most common symptoms among individuals with multiple sclerosis (MS). The imbalance of inflammatory cytokines in the brain causes mental fatigue. It is believed that aerobic exercise may moderate the level of inflammation of cytokines and thus reduce mental fatigue. This study was conducted to investigate the effect of swimming aerobic training on pro-inflammatory factors (interleukin 6) and anti-inflammatory factors (interleukin 10) to evaluate mental fatigue in the brains of female mice after EAE induction. In this research, 21 mice (8 weeks old, 18 to 20 grams) were divided into three groups: healthy control, EAE control, and EAE swimming aerobic exercise. The animals in the training group performed moderate-intensity swimming exercises for 4 weeks, with 5 sessions per week, each session lasting 30 minutes. The western blot method was used to analyze the research variables. The results showed no significant difference in the amount of IL-6 between the EAE group and the swimming training group, but the amount of IL-10 in the swimming training group showed a significant increase compared to the EAE group. The ratio of IL-10/IL-6 values between the swimming training group and the EAE group was also not significant. It seems that moderate-intensity swimming aerobic exercises, without changing the pro-inflammatory factor, along with increasing the anti-inflammatory factor IL-10, can lead to an improvement in the balance of the inflammatory index and a reduction in fatigue in the EAE group and the swimming exercise group.
