PRAS40 is expressed in all types of body tissues and is present in the muscle growth pathway and has multiple phosphorylation sites. Studies have shown that PRAS40 plays a role in regulating cell growth. The aim of this study was to evaluate the effect of six weeks of resistance training and whey protein supplementation on PRAS40 and biceps hypertrophy in male Wistar rats
Method:This developmental experimental study was carried out in 1402 year. 23 eight-week-old male Wistar rats (250 grams) were randomly divided into three groups: resistance training, resistance training+ supplement, and control. After two weeks of orientation, the training groups completed six weeks of resistance training, climbing the ladder five days a week. The training +supplement group received whey protein (2.05 g/kg dose) through gavage. 48 hours after the last training, a blood sample was taken and the gastrocnemius muscle was removed, frizzed, and saved to evaluate the expression of the PRAS40 gene.
Findings: Six weeks of resistance training with whey supplement caused a significant decrease in PRAS40 gene expression and an increase in body and muscle weight in the exercise and supplement + exercise groups.
Conclusion: The resistance training protocol along with her supplement can lead to muscle hypertrophy and activate the anabolic pathways in the muscle through the suppression of the PRAS40 pathway.
