Showing 2 results for Continuous Training
Mr Akbar Ganjkhani, Dr Tahereh Bagharpour, Dr Nematul Lae Nemati,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction: The aim of the present study was to investigate the effect of high-intensity interval training and continuous training on the serum levels of fetuin A and fetuin B in obese men.
Method: For this purpose, after homogenization, 45 obese males (Weight: 94.65±2.02 kg, Age: 26±5 yrs, BMI: 33.62±1.41 kg.m2) were randomly divided into 3 groups: control group (15 people), continuous training group (15 people), and interval training group (15 people) based on individual characteristics. The training groups were done in 12 weeks and 3 sessions per week. Interval training consisted of 6 bursts of 3-minute at 90% of maximal oxygen uptake (VO2 max) running, with 3 minutes of active recovery between each burst at 50% VO2 max running on a treadmill. Continuous training consisted of 50 minutes of running at 70% of VO2 max running on a treadmill. Blood samples were taken before and 48 hours after the last training session and were used for index analysis using an ELISA device.
Results: Analyses covariance test for the plasma levels of fetuin A and fetuin B showed that the difference between groups (control, MICT and HIIT) was statistically significant (p<0.001). According to the results of post hoc Bonferroni test for fetuin A level, there is a significant difference between the HIIT (p<0.001) and MICT (p=0.007) groups with the control group. Also, based on the results of post hoc Bonferroni test for fetuin B levels, there is a significant difference between the HIIT (p<0.001) and MICT (p<0.001) groups with the control group. In addition, fetuin B reduction in the HIIT group compared to MICT group was statistically significant (p<0.001).
Conclusion: The present results showed that although both MICT and HIIT had positive effects on reducing plasma levels of hepatokines (fetuin-A and fetuin-B), HIIT was more effective in influencing these variables. Specifically, HIIT resulted in a greater reduction in fetuin-B levels compared to MICT, while no significant difference was observed between the training groups in terms of fetuin-A levels.
Younes Sarkabood, Mohamadreza Kordi, Siroos Choobineh, Fatemeh Nasery,
Volume 0, Issue 0 (11-2019)
Abstract
Abstract
Introduction: Oxidative stress and neuroinflammation are key mechanisms in the pathophysiology of epilepsy. Physical activity plays a role in controlling and improving epileptic symptoms. This study aimed to investigate the effects of moderate-intensity continuous training (MICT) on the activity of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), the levels of HMGB1 and IL-10 proteins, and seizure severity in the hippocampus of epileptic rats.
Methods: Thirty-two male Wistar rats (6–8 weeks old; mean body weight: 226.625 ± 14.966 g) were randomly assigned to four groups: epilepsy, control, sham, and epilepsy + MICT. After completion of the 8-week training protocol, SOD and GPx activities were measured by ELISA, hippocampal HMGB1 and IL-10 levels were assessed by Western blotting, and seizure severity was evaluated using the Racine scale. Data were analyzed using one-way analysis of variance (ANOVA) and the Mann–Whitney U test in SPSS.
Results: Epilepsy induction led to decreased SOD (p < 0.02) and GPx (p < 0.001) activities, increased HMGB1 levels (p < 0.001), decreased IL-10 levels (p < 0.001), and increased seizure severity. MICT increased GPx activity (p < 0.048) and reduced HMGB1 levels (p < 0.001) in the training group compared with the epilepsy group. Although SOD activity (p = 0.953) and IL-10 levels (p = 0.198) did not change significantly, seizure severity was significantly reduced in the trained group.
Conclusion: Moderate-intensity continuous training appears to exert protective effects and reduce seizure severity in epileptic rats by strengthening the antioxidant defense system and attenuating neuroinflammation.
