Dr Sepideh Jafariyan, Dr Amirabbas Monazzami, Dr Tuoraj Ahmadijouybari, Dr Kheirollah Yari Khalilani,
Volume 0, Issue 0 (11-2019)
Abstract
Abstract
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most prevalent chronic liver disorder. Aerobic exercise is a key non-pharmacological strategy for MAFLD management, yet the impact of different training intensities remains unclear. This study investigated the effects of eight weeks of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on non-invasive liver indices, body composition, and metabolic markers in middle-aged women with MAFLD.
Methods: In this clinical trial, 41 women with MAFLD (41.39 ± 6.16 years; BMI: 32.14 ± 3.36 kg/m²) were randomly assigned to HIIT, MICT, or control groups. MICT involved 30–45 minutes at 60–70% heart rate reserve, while HIIT included 4–6 bouts of 30 seconds at 50–100–110% of maximal aerobic speed. Body composition (weight, BMI, BAI, ABSI), steatosis (HSI, FSI, LFS), fibrosis (NFS, NRS, FIB-4, FIB-5, APRI), and metabolic indices (LAP, CMI) were measured before and after the intervention. Statistical analyses included paired t-tests, one-way ANOVA, and GLMRM (p < 0.05).
Results: Both HIIT and MICT significantly reduced weight, BMI, BAI, and LFS. ABSI increased in control. HSI decreased following HIIT, while FSI decreased after MICT. Among fibrosis indices, only FIB-5 showed a significant reduction in MICT compared to HIIT, and NRS decreased in MICT compared to control. LAP decreased in both training groups relative to control, whereas CMI decreased only in MICT.
Conclusion: Although MICT demonstrated superiority in certain parameters, HIIT elicited comparable effects in a shorter duration and may represent an efficient strategy for the clinical management of MAFLD.
Fadideh Alabaf Yousefi, Roghayeh Pouzesh Jadidi, Jabbar Bashiri, , Javad Vakili,
Volume 19, Issue 22 (12-2021)
Abstract
Background and Objective: the aim was to investigate the effects of 12 weeks of High Intensity Interval Training (HIIT) and curcumin supplementation on expression levels of FSTL1 and Smad7 and also Type I, III and IV collagens in rat model with myocardial infraction (MI). Methodology: 48 male rats were randomized into five groups of Reference, HIIT, Curcumin, Concomitant (HIIT+ Curcumin) and Control, following isoproterenol induced myocardial infarction. After Reference group execution in order to conform the MI, curcumin was administrated through oral gavage 15 mg/kg.day. HIIT sessions were conducted for five days per week, each session for 60 minutes, consisted of 10 bouts (each for 4 min) of running repetitions at 85-90% of v VO2 peak separated by 2 min active rest intervals between running periods. Left ventricular FSTL1, Smad7 and also type I, III and IV collagens expression level was detected by western blotting. Results: In all three intervention groups of HIIT, Curcumin and Concomitant, the cardiac weight was significantly higher (p=0.001, p=0.018 and p=0.001 respectively), while type IV collagen expression level was significantly lower (p=0.001 in any circumstances) than Control group. However, only in the Concomitant group, a significantly lower type III collagen (p=0.033) expression level as well as higher FSTL1 (P=0.001) and Smad7 (P=0.008) expressions were recorded, compared to the Control group. Conclusion: A diminished cardiac type IV collagen expression level in accompany with a zero mortality rate in all three interventions could likely imply on the safety of HIIT as well as curcumin supplementation to suppress post infraction myocardial fibrosis. However, only concomitant intervention could decrease infracted left ventricular type III collagen expression level, with an elevated FSTL1 and Smad7 expressions, which outlines their synergistic prescription to achieve better results. However, more researches remains to be done because of the lack of evidence and study limitations.
