Showing 2 results for Metabolic Factors
Dr Fatemeh Kazeminasab, Miss Motahareh Mohebinejad, Dr Karim Azali Alamdari,
Volume 0, Issue 0 (11-2019)
Abstract
Background and purpose: Excessive fat deposition is associated with cardiovascular diseases, diabetes as well as hypertension. The aim of this study was to determine the net effect size of high intensity interval training (HIIT) on some factors associated with insulin sensitivity in adults with overweight and obesity.
Materials and methods: A search for English articles was conducted in Web of Science, Scopus, and PubMed databases without limiting the year of publication until February 2023. To calculate the effect size, WMD and 95% confidence interval were calculated using random effect model. Fixed effect model meta regression was used to determine treatment effects associations with other variables.
Results: In total, 13 studies with 446 adults with overweight and obesity (149 females, and 317 males) with 24.7-57 years old were included in the present meta-analysis. The results showed that HIIT caused a significant decrease in fasting glucose [WMD=-8.65 mg/dL, P=0.002], fasting insulin [WMD=-1.88 U/L P=0.005], and diastolic blood pressure (DBP) [WMD=-3.33 mmHg. Weak correlations were observed in between HIIT’s net effect on DBP and insulin (r=-0.32, p=0.019) as well as with subjects’ age (r=-0.29, p=0.037) respectively in meta-regression assessments.
Conclusion: The rate of DBP reduction is sharper and these changes are also correlated with age. Therefore, HIIT is suggested as a Non-pharmacological Approach to prevent against future cardiometabolic risk factors in this population.
Setare Beyhaghi, Neda Khaledi, Doctor Hossein Askari,
Volume 20, Issue 23 (9-2022)
Abstract
Recent studies indicate that environment can modify skeletal muscle gene expression and transcriptional factors in offspring genes. Therefore, exercising can lead to changes in the gene expression of the future generations. One of the important metabolic factors is PDK4, which is known as the main factor in Pyruvate Dehydrogenase Complex (PDC). This study examined the effects of maternal exercise on PDK4 expression in slow and fast twitch (soleus and EDL) muscles of male offspring. Twenty Sprague-Dawley rats were divided to three training groups: before pregnancy (TBP), during pregnancy (TDP) and before and during pregnancy (TBDP) and pregnancy without training (control) group. Training groups were running on a treadmill for four, three and seven weeks, respectively. Two months after the birth of the offspring, 6 male rats were chosen randomly from the offspring of each group. The samples were anesthetized using Ketamine (90 mg/kg) and Xylazine (10 mg/kg) and their soleus and EDL muscles were removed immediately for examine. Gene expression of offspring muscles were analyzed using real-time RT-PCR. Fisher test were used to analyze the difference between the training and the control group. PDK4 expression of offspring were significantly increased in all groups except for EDL muscle of the TBP group. According to the results, it seems likely maternal exercise training can affect the metabolic regulation in the offspring by increasing the expression of some metabolic genes.
