Showing 2 results for Shafizadeh esfandabadi
Azadeh Niknejad, Alireza Shafizadeh Esfandabadi, Fatemeh Abdollahi Sarvestani,
Volume 10, Issue 1 (6-2023)
Abstract
The emergence of new viruses has always been a threat to the health of people around the world, the latest example of it is the new strains of the coronavirus (SARS-CoV-2) and the resulting acute respiratory distress syndrome (ARDS). The current situation underscores the importance of rapidly producing low-cost stable vaccines that do not require refrigeration equipment for storage and transportation. However, most vaccines are not yet available in developing countries due to import costs and storage and transportation needs. Therefore, the vaccine must be affordable for developing countries so that vaccination can be carried out on a large scale. Herbal vaccines are more cost-effective than other types of vaccines and production methods and can be produced in large quantities. In addition, herbal vaccines have other benefits that are discussed in this article. However, given that an herbal medicinal product is to be used as a vaccine in a semi-processed form (such as mashed potatoes or tomato paste), specific regulatory reviews must apply to injectable vaccines. Products should also be applied to evaluate their side effects clinically. The current review article investigates the opportunities and challenges of producing plant-based vaccines to deal with diseases like Coronavirus disease (COVID-19(.
Dr Behnaz Bakhshandeh, Alireza Shafizadeh Esfandabadi, Negin Kiaei, Mohammad Hosien Karimi,
Volume 12, Issue 1 (3-2025)
Abstract
Stem cells have received serious attention from the medical industry based on their unique abilities and characteristics for precise and personalized medical approaches. To optimize and modify the behavioral characteristics of these cells for various clinical and research applications, it is usually necessary to create phenotypic changes resulting from permanent or transient genetic manipulations in these cells. Previously radiation and chemical reagents were used for random mutation induction in their genome but today, with the development of targeted modification tools like nucleases, it is possible to change only the desired gene and trait both inside the genome and episomally. Favorable gene transferring is accomplished with the help of different biological, chemical, or physical mediators and procedures. This literature review addressed the importance and necessity of stem cell manipulations, stem cell genetic modification procedures and advantages and disadvantages of each method, as well as available solutions to improve the efficiency and security of mentioned methods for clinical approaches.
