The aim of this research was study the mediating role of mindfulness in the relationship between extraversion/neuroticism with mental well being. In the descriptive (corelational) study, 152 Kharazmi university students (61 male, 91 female) were randomly selected and they answered the short-form Revised Eysenck Personality Questionnaire (EPQR-S) and the Mindful Attention Awareness Scale (MAAS). Also, for assessment of mental well being used the Five-item Satisfaction with Life Scale (SWLS) and the Positive and Negative Affect Scale (PANAS). Results showed the positive relationship between extraversion with mental well being and mindfulness and the negative relationship between neuroticism with mental well being and mindfulness. Hierarchical regression analysis showed mindfulness have mediating role in the relationship between extraversion and positive affect. Also, mindfulness is mediate role in the relationship between neuroticism and negative affect and in the relationship between neuroticism and life satisfaction
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