Journal of

Cancer, as one of the most prevalent chronic and life-threatening diseases, is accompanied by numerous physical and psychological challenges, including chronic pain that affects patients' quality of life. The present study aimed to predict pain tolerance based on spiritual well-being and self-control in cancer patients. This descriptive-correlational study was conducted on a population of 260 cancer patients referred to Nemazi Hospital in Shiraz in 2024, with a sample of 150 individuals selected via convenience sampling. Research instruments included the Pain Catastrophizing Scale (Sullivan et al., 1995; for inverse measurement of pain tolerance), the Spiritual Well-Being Scale (Paloutzian & Ellison, 1982), and the Self-Control Scale (Tangney et al., 2004), with reliability confirmed by Cronbach's alpha ranging from 0.80 to 0.85. Data were analyzed using Pearson correlation and multiple regression in SPSS-21 software. Pearson correlation results indicated significant positive relationships between spiritual well-being (r=0.285, p<0.001), self-control (r=0.328, p<0.001), and pain tolerance. Regression analysis revealed that spiritual well-being and self-control together explained 36% of the variance in pain tolerance (R²=0.360, F=56.993, p<0.001). Spiritual well-being and self-control are effective predictors of pain tolerance in cancer patients, and it is recommended to integrate interventions focused on enhancing these factors into clinical programs to improve patients' quality of life.