The purpose of this study was to compare the effectiveness of therapeutic interventions of acceptance and commitment and mindfulness on the biological, psychological and social indicators of women with human papillomavirus.This study was a semi-experimental method with a pre-test-post-test design and a two-month follow-up period. The statistical population included all female patients with human papilloma virus who lived in Dubai and visited Al-Shafa Behavioral Diseases Clinic .Through purposive sampling, 45 subjects were selected and randomly allocated to either the ACT, mindfulness or the control group (n = 15 per group). Then the subjects of the two experimental groups were subjected to training based on acceptance and commitment therapy and training based on mindfulness for 8 sessions of 90 minutes. The data collection tool was DASS-21 (1993), Marlowe and Crown's (1996) Social Desirability Scale. the results, a tangible difference was spotted between the groups in the pre-and post-test stage and considering time impact on the mean virous (η2=0.888, F=222.695, p<0.001), depression (η2=0.953, F=562.146, P<0.001), anxiety (η2=0.760, F=88.843, P<0.001), stress (η2=0.953, F=405.704, P<0.001), and social desirability (η2=0.26, F=9.820, P<0.001). In general, the results showed that both methods of educational intervention were effective in women.
