The purpose of this study was to investigate the role of early maladaptive schemas and Stress Coping Strategies of mothers on the quality of life of children 1 to 6 years old during the COVID-19 Epidemic. The method of this study is descriptive-correlational. The statistical population of the study included all mothers with children aged 1 to 6 yearsThe sample consisted of 325 mothers who completed the questionnaires online. Data were collected using Early Maladaptive Scheme (YSQ- SF), Coping Inventory for Stressful Situation (Ciss), TNO-AZL Preschool Children Quality of Life Questionnaire (TAPQOL). Data was analyzed using multivariate analysis of multiple regression. Results showed 32% of quality of life of children variance during COVID-19 Epidemic can be explained by early maladaptive schemas and Stress Coping Strategies of mothers.The results of regression analyses revealed that maladaptive schemas of Emotional deprivation, Abandonment, Social Isolation, Defectiveness / Shame, Dependence, Vulnerability to harm or illness, Enmeshment/underdeveloped self and Unrelenting standards of mothers predicts on the quality of life of children during the COVID-19 Epidemic.Thus , training of appropriate strategies for mothers to reduce the maladaptive schemas and to teach proper coping strategies For increase quality of life of children is essential.