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The applications  of  electrical  stimulation of  the  brain , which include invasive and non-invasive methods , are now burgeoning in the fields of neuroscience. The aim of this study, was to investigate the effects of transcranial direct current stimulation on dorsolateral prefrontal cortex (DLPFC) in reducing the smoke craving and the rates of stress. Therefore, using random sampling and snowball method, in the population of smokers in the students of kharazmi university, we selected 20 subjects and assigned them in experimental and control group. The instrument used in this study, was the smoking urge questionnaire (SCQ) and stress subscale of depression, anxiety, stress scale (DASS). Analysis of covariance and t-test of diminished scores showed that there are significant differences between groups in rates of craving and stress in post-test stage (respectively, 0.035 & 0.000, p<0.05).in addition, the number of used cigarette reduced after interventions (0.029,p<0.05). Generally, tDCS had an effective role in reduction of smoke craving and stress in experimental group.

In this study we aimed to investigate whether anodal Transcranial   direct current stimulation (tDCS) of left and right Dorsolatera prefrontal cortex (DLPFC) could affect subjective negative /positive mood in healthy subjects. In a quasi-experimental study, participants (20 female, 20 male) were received three left anodal DLPFC/ Right anodal DLPFC and Sham stimulation (2mA, 20 min)  in a random order independent sessions. The Positive and Negative Affect Schedule (PANAS) was administered for assessing subjective mood, before and after treatment. Friedman Test and Mann-Whitny U were used for analysising data. Results indicated that left anodal tDCS over DLPFC diminish subjective report of negative mood. Moreover, the effects of tDCS on decreasing positive mood in men was greater than women. Active bifrontal tDCS in our population not only was not compatible with previous results in healthy population, but also it was similar to tDCS application in depressed population. Further studies with precise assessment of mood and emotion, and with applying different tDCS montages could generate complementary finding about the role of the DLPFC in subjective mood.