The aim of this study was to compare the cognitive emotion regulation, general health, problem-solving style and academic performance of the adolescent girls with addicted parents with nonaddicted parents ones. The research method was causal-comparative. The statistical population was all female high school students of the third District of Karaj. Using convenience sampling method, 120 students was used which was included of 60 students with addicted and 60 students with non-addicted parents. The selected students in both groups were equilized. The groups completed Cognitive Emotion Regulation, general health and problem solving questionnaires. T-test and MANOVA were used to data analysis. Results indicated that adolescents with addicted parents achieve more score in “Blaming others” item and the others achieve more score in “Putting into perspective”, “Positive refocusing”, “Positive reappraisal” and “Refocus on planning” items in Cognitive Emotion Regulation test. Adolescents with nonaddicted parents get more score in “social” context and the others have more score in “Physical”, “anxiety” and “depression” context. Problem solving score in “personal control” item for students with nonaddicted parents and score in “Avoidance” for adolescents with addicted parents is higher than others. Academic Performance of the adolescents with addicted parents was less than that of the others.