A healthy city concept aims to prevent the development of various diseases through effective urban design and land use. Shiraz city and Fars province have the highest incidence of road and pedestrian accidents. Additionally, depression among the elderly serves as a precursor to other health issues, necessitating enhanced social and healthcare initiatives to raise awareness, improve life expectancy, and foster a sense of community belonging. This study aims to measure indicators and elucidate healthy urban spaces through a smart city approach in Shiraz. It is practical in purpose and descriptive-analytical in nature and methodology. The statistical population was drawn from a group of university experts and municipal employees to gather insights on health-oriented urban development within the smart city framework. Data collection was based on comprehensive library research. To analyze the data, inferential methods were employed, including the single-sample t-test, analysis of variance (ANOVA), Scheffe's post hoc test, and factor analysis. SPSS software was utilized for data analysis. The results indicate that the indicators examined are complementary and contribute positively to the health of citizens. Furthermore, 11 factors have been identified as critical dimensions for a healthy city aligned with the smart city approach: air quality, social interaction, safety, social participation, climatic comfort, social security, access to water, sewage and waste management, social justice, urban green space, education, poverty, and employment. Ultimately, the research hypotheses have been confirmed.