An AO is an example of teleconnection pattern in the northern hemisphere’s winter. In this study, the effect of AO on the monthly minimum temperatures in the North-East region of Iran is investigated. The required statistics, including statistics monthly minimum temperatures for 17 synoptic stations of the under study area was provided from Iran Meteorological Organization’s (IRMO). Pearson correlation analysis as the main method used in this study Show an inverse relationship between minimum temperatures and most selected stations and AO index.The results of this study shows that there is a significant relationship between the AO teleconnection pattern and minimum temperatures of north-east of Iran during the cold season of the year. This shows decrease of temperature in positive phase of the AO and rise of temperature is negative phase. In terms of time correlation coefficients were calculated showed a significant negative correlation between the temperature of stations and the AO Among the studied stations, the relationship between the minimum and average monthly temperatures in Birjand and Bojnoord station more than other stations, affected by the AO pattern, has been fluctuated and significant correlation coefficients between the minimum and average temperature of Birjand and Bojnoord Stations with AO has been calculated. The effect of Arctic oscillation on mean temperature of the studied area, north-east of Iran, during the three months, January to march, and ,two months, January to February, is very distinctive against any other periods of time.