Volume 10, Issue 3 (2-2010)
2010, 10(3): 879-890 |
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Designation and construction of a plasmid containing gp96 and Her2 and in vitro expression using GFP gene. Journal title 2010; 10 (3) :879-890
URL: http://jsci.khu.ac.ir/article-1-1438-en.html
URL: http://jsci.khu.ac.ir/article-1-1438-en.html
Abstract: (5662 Views)
Abstract
Objective: DNA vaccinations using Her2 gene have shown some success in immunotherapy of Her2-expressing tumors, but the potency needs to be greatly enhanced. Heat Shock Proteins (HSPs) have shown to be potent adjuvant in immunotherapy of tumors and affect different aspects of innate and adaptive immune responses. We utilized the adjuvant effect of gp96 and attempted to gain two aims, firstly, production of a construct containing fusion of Her2 and gp96, and secondly, investigation of gene expression in the construct using green fluorescent protein (GFP) gene.
Objective: DNA vaccinations using Her2 gene have shown some success in immunotherapy of Her2-expressing tumors, but the potency needs to be greatly enhanced. Heat Shock Proteins (HSPs) have shown to be potent adjuvant in immunotherapy of tumors and affect different aspects of innate and adaptive immune responses. We utilized the adjuvant effect of gp96 and attempted to gain two aims, firstly, production of a construct containing fusion of Her2 and gp96, and secondly, investigation of gene expression in the construct using green fluorescent protein (GFP) gene.
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