دوره 12، شماره 2 - ( 6-1404 )                   جلد 12 شماره 2 صفحات 0-0 | برگشت به فهرست نسخه ها

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Hanachi P, Adibi Z, Gharari Z, Attaran B, Zarrin Ghalami R. Investigation of Phytochemical and Antioxidant Content of Arctium lappa Extract and its Antimicrobial Properties. NBR 2025; 12 (2)
URL: http://nbr.khu.ac.ir/article-1-3731-fa.html
Hanachi Parichehr، Adibi Zahra، Gharari Zahra، Attaran Bahareh، Zarrin Ghalami Roshanak. Investigation of Phytochemical and Antioxidant Content of Arctium lappa Extract and its Antimicrobial Properties. یافته‌‌های نوین در علوم زیستی. 1404; 12 (2)

URL: http://nbr.khu.ac.ir/article-1-3731-fa.html

Investigation of Phytochemical and Antioxidant Content of Arctium lappa Extract and its Antimicrobial Properties
Parichehr Hanachi* ، Zahra Adibi ، Zahra Gharari ، Bahareh Attaran ، Roshanak Zarrin Ghalami
Department of Biotechnology, Faculty of Biological Science, Alzahra University, Tehran, Iran. ، p.hanachi@alzahra@edu.ir
چکیده:   (266 مشاهده)
Plant secondary metabolites like phenols and flavonoids neutralize free radicals and are linked to antioxidant and cytotoxic activities. Due to rising drug resistance in pathogens such as Salmonella paratyphi, Bacillus cereus, Escherichia coli, and Staphylococcus aureus, medicinal herbs are increasingly explored for antimicrobial properties. This study evaluated the total phenolic content (TPC), total flavonoid content (TFC), antioxidant capacity, and antibacterial effects of Arctium lappa. TPC, TFC, and antioxidant levels were measured using Folin-Ciocalteu, Aluminum chloride, FRAP, and DPPH assays, respectively. Antibacterial activities were assessed by microdilution broth and disc diffusion methods to determine MIC50 and MBC values. Results showed that A. lappa ethanolic extract, prepared with diluted water and the boiling method, had the highest flavonoid content (7.9 ± 0.40 mg/g DW). The leaves and flowers extract, using methanol and the boiling method, had the highest phenolic content (62.13 ± 0.73 mg/g DW) and antioxidant capacity. The ethanolic extract of A. lappa leaves also demonstrated the strongest antibacterial activity, with an MBC of 0.140 mg/mL and an 8 ± 0.4 mm inhibition zone against all tested bacteria. These findings suggest A. lappa bioactive compounds, particularly phenolics and flavonoids, offer promising potential for treating bacterial infections in pharmacognostic applications.
 
واژه‌های کلیدی: Antibacterial، Antioxidant، Arctium lappa، Phenolic compounds، Flavonoids
     
نوع مطالعه: مقاله پژوهشی | موضوع مقاله: میکروبیولوژی
دریافت: 1404/1/18 | ویرایش نهایی: 1404/7/6 | پذیرش: 1404/6/10 | انتشار: 1404/7/5 | انتشار الکترونیک: 1404/7/5
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