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The present study was aimed at investigating the role of patience to predict the difficulty of emotional regulation in students. Research participants were 400(155 males and 245 females) bachelor students of Shiraz University that were chosen using the multi-stage cluster sampling method from various colleges of  the University, and they have responded to Difficulties in Emotion Regulation scale(  (DERS) and patience scale. The reliability of the research instruments was determined  by Cronbach's alpha coefficient and their validity was determined by factorial analysis. Results of path analysis using the structural equation in AMOS software showed that the patience is a negative and significant predictor of difficulties in emotion regulation, and by increasing the patience score(grade) and its components, the score of difficulites in emotion regulation is reduced. Accordingly, it is proposed that patience education and its components are used as the major center of emotional control. These educations, in addition to reinforce the moral virtues of students, will be effective help in facilitate the emotions regulation.