In this study is simulation of role of topography in thickness and Inland penetration of sea-breeze in southern coast of the Caspian Sea. The RegCM4 as a regional scale climate model coupled with a lake model and also the reanalysis data of NCEP / NCAR used to determine of the initial conditions of the model. The model was run during the peak of sea breeze on the southern coast of the Caspian Sea (July 2002) in both conditions (with mountains) and (without mountains). the outputs indicated that in without topography condition depth of the sea breeze will increase to the current position the southern slopes of the Alborz Mountains ( latitude ᵒ35 ) but the land breeze in the area is gone. The maximum speed and changes in wind direction observed on the coast southeast and central Alborz respectively. In addition with non-topography conditions, the thickness of sea breeze in different areas significantly has increased with the highest rate on the eastern coast (longitude ᵒ53).